abstract：:Non-small cell lung cancer (NSCLC) patients with epithelial growth factor receptor (EGFR) mutations and bone metastases are often concurrently administered tyrosine kinase inhibitors (TKIs) and bisphosphonates. Yet, the effects and mechanisms of these agents are unclear. In the present study, we aimed to ascertain whe...

journal_title：Oncology reports

authors： Feng C,Liu X,Li X,Guo F,Huang C,Qin Q,Wang Y

更新日期：2016-06-01 00:00:00

abstract：:The present study aimed to assess the in vitro and in vivo magnetic resonance imaging (MRI) features of chlorotoxin (CTX)-conjugated superparamagnetic iron oxide (SPIO) nanoprobes. CTX-conjugated nanoprobes were composed of SPIO coated with polyethylene glycol (PEG) and conjugated with CTX. The nanoprobes were termed ...

journal_title：Oncology reports

authors： Chen Z,Xiao EH,Kang Z,Zeng WB,Tan HL,Li HB,Bian DJ,Shang QL

更新日期：2016-05-01 00:00:00

abstract：:In the present study, we analyzed the influence of brefeldin A (BFA) and castanospermine (CAS) on the activity, stability and localization of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in various resistant cell lines. The impact of BFA and CAS on cell viability was assessed using the MTT test. We...

journal_title：Oncology reports

authors： Wojtowicz K,Januchowski R,Sosińska P,Nowicki M,Zabel M

更新日期：2016-05-01 00:00:00

abstract：:In the present study, a novel signaling pathway of microRNA-141 (miR-141)/fused in sarcoma (FUS) was investigated in neuroblastoma (NB). Gene expression of miR-141 was evaluated in 6 NB cell lines. IMR-32 and SH-SY5Y cells were transduced with the miR-141 mimic lentivirus. The effects of miR-141 upregulation on cell p...

journal_title：Oncology reports

authors： Wang Z,Lei H,Sun Q

更新日期：2016-05-01 00:00:00

abstract：:In order to investigate the involvement of the IER3/PP2A-B56γ/ERK-positive feedback loop, which leads to sustained phosphorylation/activation of ERK in carcinogenesis, we immunohistochemically examined the expression of IER3 and phosphorylated ERK in lung tumor tissues. IER3 was overexpressed in all cases of adenocarc...

journal_title：Oncology reports

authors： Ito T,Ozaki S,Chanasong R,Mizutani Y,Oyama T,Sakurai H,Matsumoto I,Takemura H,Kawahara E

更新日期：2016-05-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promise for cancer therapy due to its unique capacity to selectively trigger apoptosis in cancer cells. However, TRAIL therapy is greatly hampered by its resistance. A preclinical successful strategy is to identify combination treatments that sensit...

journal_title：Oncology reports

authors： Li L,Wen XZ,Bu ZD,Cheng XJ,Xing XF,Wang XH,Zhang LH,Guo T,Du H,Hu Y,Fan B,Ji JF

更新日期：2016-05-01 00:00:00

abstract：:Sedum sarmentosum Bunge, a traditional Chinese herbal medicine, has a wide range of clinical applications including antibiosis, anti-inflammation and anti-oxidation. In the present study, we identified that its extract (SSBE) exerts pancreatic anticancer activity in vitro and in vivo. In the cultured pancreatic cancer...

journal_title：Oncology reports

authors： Bai Y,Chen B,Hong W,Liang Y,Zhou M,Zhou L

更新日期：2016-05-01 00:00:00

abstract：:Eukaryotic elongation factor 2 (eEF2) is an essential factor for protein synthesis. Previous studies have shown that the eEF2 gene was overexpressed and plays an oncogenic role in various types of cancers and that eEF2 gene product elicited both humoral immune responses to produce eEF2-specific IgG autoantibody in can...

journal_title：Oncology reports

authors： Nakajima H,Murakami Y,Morii E,Akao T,Tatsumi N,Odajima S,Fukuda M,Machitani T,Iwai M,Kawata S,Hojo N,Oka Y,Sugiyama H,Oji Y

更新日期：2016-04-01 00:00:00

abstract：:Emodin (EMO) has been shown to possess pleiotropic anticancer capabilities in many types of cancer, including epithelial ovarian cancer (EOC). Inhibitory efficacy of EMO on EOC invasion and migration was previously observed, however, the underlying mechanisms have not been completely elucidated. The present study is a...

journal_title：Oncology reports

authors： Hu C,Dong T,Li R,Lu J,Wei X,Liu P

更新日期：2016-04-01 00:00:00

abstract：:Pancreatic cancer is usually diagnosed in the advanced stages and is sensitive to only few therapies. The forkhead box L1 (FOXL1) and protein phosphatase 2A (PP2A) have been recognized to be tumor suppressive in human pancreatic cancers. In the present study, we co-expressed the two tumor suppressive molecules with a ...

journal_title：Oncology reports

authors： Li Y,Yu D,Sheng W,Song H,Li Y,Dong M

更新日期：2016-04-01 00:00:00

abstract：:Epigenetic changes as well as genetic changes are mechanisms of tumorigenesis. We aimed to identify novel genes that are silenced by DNA hypermethylation in hepatocellular carcinoma (HCC). We screened for genes with promoter DNA hypermethylation using a genome-wide methylation microarray analysis in primary HCC (the d...

journal_title：Oncology reports

authors： Yamada N,Yasui K,Dohi O,Gen Y,Tomie A,Kitaichi T,Iwai N,Mitsuyoshi H,Sumida Y,Moriguchi M,Yamaguchi K,Nishikawa T,Umemura A,Naito Y,Tanaka S,Arii S,Itoh Y

更新日期：2016-04-01 00:00:00

abstract：:The incidence of malignant melanoma has increased greatly in recent decades presenting a high mortality rate despite intensive efforts in this area of research. Recent studies indicate that the chemokine receptor 4 (CXCR4) plays a critical role in cancer. Thus, it has been reported that CXCL12 binding to CXCR4 initiat...

journal_title：Oncology reports

authors： André ND,Silva VA,Watanabe MA,De Lucca FL

更新日期：2016-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are novel tools for cancer therapy. Frizzled7 (FZD7) is an important co-receptor in the WNT signaling pathway. The WNT signaling pathway is aberrantly activated in Helicobacter pylori (H. pylori)‑infected gastric cancer cells. However, the role of FZD7 in H. pylori‑induced gastric tumorigenesis rema...

journal_title：Oncology reports

authors： Geng Y,Lu X,Wu X,Xue L,Wang X,Xu J

更新日期：2016-04-01 00:00:00

abstract：:Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive ...

journal_title：Oncology reports

authors： Kim YR,Kang TW,To PK,Xuan Nguyen NT,Cho YS,Jung C,Kim MS

更新日期：2016-04-01 00:00:00

abstract：:Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial NADP-dependent isocitrate dehydrogenase. It is considered to be a novel tumor suppressor in several types of tumors. However, the role and related mechanism of IDH2 in osteosarcoma remain unknown. The expression and significance of IDH2 were investigated by immunohi...

journal_title：Oncology reports

authors： Yi WR,Li ZH,Qi BW,Ernest ME,Hu X,Yu AX

更新日期：2016-04-01 00:00:00

abstract：:Cachexia accompanied by muscle wasting is a key determinant of poor prognosis in cancer patients and cancer‑related death. Previous studies have demonstrated that inflammatory cytokines such as interleukin‑6 (IL‑6), tumor necrosis factor‑α (TNF‑α), IL‑1 and interferon‑γ (IFN‑γ) secreted from host cells and tumor cells...

journal_title：Oncology reports

authors： Kim A,Im M,Ma JY

更新日期：2016-03-01 00:00:00

abstract：:Angiogenesis is a key factor in the growth and dissemination of malignant diseases, including breast cancer, with significant implications for its clinical management. It is known that microRNAs (miRNAs) play important roles in regulating tumor properties in cancers. However, whether miR-497 contributes to breast canc...

journal_title：Oncology reports

authors： Wu Z,Cai X,Huang C,Xu J,Liu A

更新日期：2016-03-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most lethal malignancies worldwide. To reduce its high mortality, sensitive and specific biomarkers for early detection are urgently needed. Recent studies have reported that tumor-specific long non-coding RNAs (lncRNAs) seem to be potential biomarkers for the early diagnosis and trea...

journal_title：Oncology reports

authors： Li C,Liang G,Yao W,Sui J,Shen X,Zhang Y,Ma S,Ye Y,Zhang Z,Zhang W,Yin L,Pu Y

更新日期：2016-03-01 00:00:00

abstract：:A growing number of studies suggest that the hepatitis B virus X protein (HBx) enhances the protein stability of the hypoxia-inducible factor-1α (HIF-1α). However, the relationship between hepatitis B virus (HBV), HBx and hypoxia-inducible factor-2α (HIF-2α) has not yet been fully elucidated. Immunohistochemical analy...

journal_title：Oncology reports

authors： Hu JL,Liu LP,Yang SL,Fang X,Wen L,Ren QG,Yu C

更新日期：2016-03-01 00:00:00

abstract：:Sirtuin 6 (SIRT6) is a member of the mammalian NAD+‑dependent deacetylase sirtuin family that acts to maintain genomic stability and to repress genes. SIRT6 has recently been reported to be a tumor suppressor that controls cancer metabolism, although this effect of SIRT6 is still in dispute. Moreover, the role of SIRT...

journal_title：Oncology reports

authors： Feng J,Yan PF,Zhao HY,Zhang FC,Zhao WH,Feng M

更新日期：2016-03-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) occurs frequently in cervical carcinogenesis. miRNAs function as tumor-suppressors or oncogenes and are involved in tumor behavior. However, the expression and function of miR-27b in cervical carcinogenesis remain unknown. In the present study, we observed that miR-27b was significa...

journal_title：Oncology reports

authors： Yao J,Deng B,Zheng L,Dou L,Guo Y,Guo K

更新日期：2016-03-01 00:00:00

abstract：:Cancer cells in ascites are usually exposed to a hypoxia tumor microenvironment and utilize enhanced glycolysis which produces energy and metabolizes nutrients to support proliferation. Vesicular stomatitis virus (VSV) is an oncolytic virus that relies on the host cellular metabolism for replication. We tested the eff...

journal_title：Oncology reports

authors： Zhou Y,Wen F,Zhang P,Tang R,Li Q

更新日期：2016-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that are involved in tumor initiation and development by suppressing target gene expression. miRNA-154 has been shown to be important in tumorigenesis in many types of cancers. However, its role in osteosarcoma (OS) remains unknown. In the present study, we focused on the r...

journal_title：Oncology reports

authors： Zhou H,Zhang M,Yuan H,Zheng W,Meng C,Zhao D

更新日期：2016-03-01 00:00:00

abstract：:DNA intrastrand cross-linking agents such as oxaliplatin induce DNA double-strand breaks (DSBs) during DNA repair and replication. In the present study, we hypothesized that DNA intrastrand cross-linking agents may significantly benefit colorectal cancer patients with deficiencies in DSB repair. Seventy-eight patients...

journal_title：Oncology reports

authors： Ihara K,Yamaguchi S,Ueno N,Tani Y,Shida Y,Ogata H,Domeki Y,Okamoto K,Nakajima M,Sasaki K,Tsuchioka T,Mitomi H,Kato H

更新日期：2016-03-01 00:00:00

abstract：:MicroRNAs (miRs) have emerged as prospective tools for human cancer therapy, including hepatocellular carcinoma (HCC) therapy. Previous studies have suggested that miR-381 functions as oncogenic or tumor-suppressive miRs in other cancer types. However, the role of miR-381 in HCC remains unknown. The present study inve...

journal_title：Oncology reports

authors： Zhang Q,Zhao S,Pang X,Chi B

更新日期：2016-03-01 00:00:00

abstract：:MicroRNA-17-5p has been proven upregulated in many human malignancies and correlated with tumor progression. However, its expression and clinical significance in osteosarcoma is still unclear. Thus, the aim of the present study was to explore the effects of miR-17-5p in osteosarcoma tumorigenesis and development. The ...

journal_title：Oncology reports

authors： Wang W,Zhang L,Zheng K,Zhang X

更新日期：2016-03-01 00:00:00

abstract：:The emerging role of microRNA-181A (miR-181A) in CRC patients with late liver metastases was studied. In the present study we investigated the association between expression and mechanism of miRNA-181A, liver metastasis and prognosis of colorectal cancer (CRC). The expression of miR-181A and PTEN in CRC patients with ...

journal_title：Oncology reports

authors： Li Z,Wang H,Xu Z,Sun Y,Han J

更新日期：2016-03-01 00:00:00

abstract：:Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) treatment is effective for the treatment of primary tumors, but not sufficient for the treatment of metastatic tumors, likely owing to the effects of the tumor microenvironment. In this study, we aimed to determine the therapeutic effects of combined treatment with a matr...

journal_title：Oncology reports

authors： Li M,Xing S,Zhang H,Shang S,Li X,Ren B,Li G,Chang X,Li Y,Li W

更新日期：2016-03-01 00:00:00

abstract：:Cellular senescence is a state of irreversible growth arrest that can be triggered by multiple mechanisms, including telomere shortening, the epigenetic derepression of the INK4α/ARF locus and DNA damage. Senescence has been considered a tumor‑suppressing mechanism that permanently arrests cells at risk for malignant ...

journal_title：Oncology reports

authors： Hwang HJ,Jung SH,Lee HC,Han NK,Bae IH,Lee M,Han YH,Kang YS,Lee SJ,Park HJ,Ko YG,Lee JS

更新日期：2016-02-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) endows cancer cells with enhanced invasive and metastatic potential during cancer progression. Fractalkine, also known as chemokine (C-X3-C motif) ligand 1 (CX3CL1), the only member recognized so far that belongs to the CX3C chemokine subfamily, was reported to participate in...

journal_title：Oncology reports

authors： Tang J,Xiao L,Cui R,Li D,Zheng X,Zhu L,Sun H,Pan Y,Du Y,Yu X

更新日期：2016-02-01 00:00:00

abstract：:Histone deacetylase (HDAC) 4 is an emerging target in cancer therapeutics, but little is known about the function of HDAC4 in gynecologic malignancies. Therefore we investigated the mechanism of HDAC4 promoting the proliferation of epithelial ovarian cancer cells (OV). In this study, we observed that the proliferation...

journal_title：Oncology reports

authors： Shen YF,Wei AM,Kou Q,Zhu QY,Zhang L

更新日期：2016-02-01 00:00:00

abstract：:Breast cancer metastasizes to the bone in a majority of patients with advanced disease resulting in bone destruction. The underlying mechanisms are complex, and both processes are controlled by an interaction between locally and systemically derived signals. Clinically, breast cancer patients with depression have a hi...

journal_title：Oncology reports

authors： Zong JC,Wang X,Zhou X,Wang C,Chen L,Yin LJ,He BC,Deng ZL

更新日期：2016-02-01 00:00:00

abstract：:It is well known that crucifers have antitumor effects and 3,3'-diindolylmethane (DIM) is one of the major bioactive components, and the associated molecular mechanisms in a short-term high-dose manner are widely discussed. However, the antitumor effects of DIM in a long-term low-dose manner in nasopharyngeal carcinom...

journal_title：Oncology reports

authors： Li F,Chen C,Chen SM,Xiao BK,Tao ZZ

更新日期：2016-02-01 00:00:00

abstract：:Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. However, few studies have defined functional roles and mechanis...

journal_title：Oncology reports

authors： Yan L,Wang Y,Wang ZZ,Rong YT,Chen LL,Li Q,Liu T,Chen YH,Li YD,Huang ZH,Peng J

更新日期：2016-01-01 00:00:00

abstract：:Hypoxic tumor cells are known to be more resistant to conventional chemotherapy and radiation than normoxic cells. However, the effects of 2-methoxyestradiol (2-ME), an anti-angiogenic, antiproliferative and pro-apoptotic drug, on hypoxic lung cancer cells are unknown. The aim of the present study was to compare the e...

journal_title：Oncology reports

authors： Aquino-Gálvez A,González-Ávila G,Delgado-Tello J,Castillejos-López M,Mendoza-Milla C,Zúñiga J,Checa M,Maldonado-Martínez HA,Trinidad-López A,Cisneros J,Torres-Espíndola LM,Hernández-Jiménez C,Sommer B,Cabello-Gutiérrez C,Guti

更新日期：2016-01-01 00:00:00

abstract：:Adoptive immunotherapy requires the isolation of CD8+ T cells specific for tumor-associated antigens, their expansion in vitro and their transfusion to the patient to mediate a therapeutic effect. MUC1 is an important adenocarcinoma antigen immunogenic for T cells. The MUC1-derived SAPDTRPA (MUC1-8-mer) peptide is a p...

journal_title：Oncology reports

authors： Atzin-Méndez JA,López-González JS,Báez R,Arenas-Del Angel MC,Montaño LF,Silva-Adaya D,Lascurain R,Gorocica P

更新日期：2016-01-01 00:00:00

abstract：:Cigarette smoke has been implicated as a major risk factor for esophageal squamous cell carcinoma (ESCC). Several lines of evidence have suggested that the promoting effect of cigarette smoking extract (CSE) on ESCC is mediated by upregulation of cyclooxygenase-2 (COX-2) expression. Yet, the underlying molecular and c...

journal_title：Oncology reports

authors： Gong J,Chu Y,Xu M,Huo J,Lv L

更新日期：2016-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers worldwide. Long non-coding RNAs (lncRNAs) have been confirmed to play a critical regulatory role in various biological processes including carcinogenesis, which indicates that lncRNAs are valuable biomarkers and therapeutic targets. The novel lncRNA prostate ca...

journal_title：Oncology reports

authors： Yang L,Qiu M,Xu Y,Wang J,Zheng Y,Li M,Xu L,Yin R

更新日期：2016-01-01 00:00:00

abstract：:Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and that it plays significant roles in tumor cell migration and invasion. The clinicopathological significance of Lxn expression and its possible correlation with CD133 expression in pancreatic ductal adenocarcinoma (PDAC) is curr...

journal_title：Oncology reports

authors： Xue Z,Zhou Y,Wang C,Zheng J,Zhang P,Zhou L,Wu L,Shan Y,Ye M,He Y,Cai Z

更新日期：2016-01-01 00:00:00

abstract：:Codonolactone (CLT), a natural product, is the major bioactive component of Atractylodes lancea, and also found in a range of other medical herbs, such as Codonopsis pilosula, Chloranthus henryi Hemsl and Atractylodes macrocephala Koidz. This sesquiterpene lactone has been demonstrated to exhibit a range of activities...

journal_title：Oncology reports

authors： Fu J,Ke X,Tan S,Liu T,Wang S,Ma J,Lu H

更新日期：2016-01-01 00:00:00